Three hundred years ago, a genetic experiment gone wrong caused the mutation of all forests on Earth. Armed with consciousness, the vegetation sought to destroy all of humankind, and the war that ensued turned the planet into a hellish dystopia. In the present day, Agito, a young boy, lives with his father in Neutral City—a village maintaining an uneasy truce with the neighboring forest. One day, Agito, on his way to collect water, becomes separated from his friend and stumbles upon a relic of the past: a girl sleeping in a mysterious machine. Agito awakens the girl, Toola Cm Sacl, and introduces her to the village. But outside forces have ulterior motives for the girl, who holds the key to restore the Earth. Misguided by Shunack, a soldier from the old world hellbent on destroying the forest, Toola follows him despite Agito's warning. Determined to save Toola and unify humankind with the forest, Agito borrows the power of the forest and pursues her. A failed DNA experiment with plants has changed the world forever. Having demolished the moon, the intelligent and aggressive plant-life has spread to the earth and destroyed the human civilization. The few humans that remain struggle to survive, while maintaining an uneasy truce with the restless forest. One day, a villager named Agito stumbles across a stasis unit hidden deep in the forest and awakens a very cute girl from the past. Having slept for the past 300 years, Toola steps into a very different and strange world. The neighbouring high-tech village of Laguna is still locked in a bitter war with the forest and when they become aware of Toola, they realize that she is the key to activating her father's final and ultimate weapon of humanity - a weapon designed to totally destroy the forest. When Toola is taken by the warriors of Laguna, Agito makes a pact with the forest to gain the strength and incredible powers to not only save her, but to stop the weapon from destroying both the forest and his village.